Mobin Karimi，医学博士

WEB资源

协会/会员

研究抽象

Immune cells play a critical role in combating infections and cancers but can also be harmful in autoimmunity and immunopathologic states. Our laboratory combines efforts in both basic research and clinical investigation to advance the understanding of cancer immunology and to develop novel immunotherapies for cancer and autoimmune disorders.

Current projects in our laboratory are to understand how the modulation of immune cells receptor signals can be used to alter immune cell functions, and the interest of developing therapeutic strategies for immune cells mediated diseases.

有几个项目正在调查中

1. Investigating the impact of manipulating TCR signal transduction pathways in normal and disease models. 更具体地说, we are interested to study the role of adaptor molecule SLP-76 in hematological malignancies and bone marrow transplantation. 我们也在调查 Tec family tyrosine kinases (ITK) that regulate lymphocyte development, activation, 和分化. Itk is a Tec family tyrosine kinase that is activated upon TCR signaling and is required for full TCR-induced activation of PLC-γ, Ca²⁺ 动员和ERK激活. We are specifically investigating the role on ITK in cytokine production, T细胞迁移, and T cells effector function and chemokine receptor expression in both normal and disease models.
2. T cells play critical roles in host defense against viruses, intra cellular microbe, and cancers. What is not clear is how the key transcription factors, t盒转录因子, T-bet and Eomesodermin (Eomes) function as effector molecule in T cells during infection and immunopathologic states. We are also examining the role of the Wnt signal pathway, and T cell factor-1 (TCF1) signaling pathway, which is necessary for Eomes expression in naïve and memory CD8⁺ 免疫病理状态下的T细胞.
3. We are examining the role of NKG2D signaling and surface expression in graph verses tumor (GVT) response after allogeneic bone marrow transplantation. 更具体地说 we are investigating the association between NKG2D expression and GVT responses, both clinically and in vitro in a cohort of HSCT recipients with acute myeloid leukemia (AML).

Rotation Projects are available in all areas

实验人员:
首席研究员莫宾·卡里米

选定的手稿

1. Mammadli, M., R. Harris, S. Mahmudlu, A. Verma, A. May, R. Dhawan, A. T. Waickman, J. M. Sen, A. 奥古斯特和我. Karimi. "Human Wnt/Beta-Catenin Regulates Alloimmune Signaling During Allogeneic Transplantation." 癌症(巴塞尔) 13, no. 15(2021年7月28日). http://dx.doi.org/10.3390/cancers13153798.
2. Mammadli, M., R. Harris, L. Suo, A. May, T. Gentile, A. T. Waickman, A. Bah, A. August, E. 纽曼梅多夫和M. Karimi. "Interleukin-2-Inducible T-Cell Kinase (Itk) Signaling Regulates Potent Noncanonical Regulatory T Cells." 临床翻译医学 11, no. 12 (Dec 2021): e625. http://dx.doi.org/10.1002/ctm2.625.
3. Mammadli, M., W. Huang, R. Harris, A. Sultana, Y. Cheng, W. Tong, J. Pu, T. Gentile, S. Dsouza, Q. Yang, A. Bah, A. 奥古斯特和我. Karimi. "Targeting Interleukin-2-Inducible T-Cell Kinase (Itk) Differentiates Gvl and Gvhd in Allo-Hsct." 前面Immunol 11 (2020): 593863. http://dx.doi.org/10.3389/fimmu.2020.593863.
4. Mammadli, Mahinbanu, 沩山黄, 丽贝卡·哈里斯, Hui Xiong, Samuel Weeks, Adriana May, 特蕾莎修女外邦人, 杰西卡Henty-Ridilla, Adam T. Waickman, Avery August, Alaji Bah, and Mobin Karimi. "Targeting Slp76:Itk Interaction Separates Gvhd from Gvl in Allo-Hsct." iScience 24, no. 4 (2021/04/23/ 2021): 102286. http://www.frontiersin.org/articles/10.3389/fimmu.2020.593863/full.
5. Weeks, S., R. 哈里斯和M. Karimi. "Targeting Itk Signaling for T Cell-Mediated Diseases." iScience 24, no. 8 (Aug 20 2021): 102842. http://dx.doi.org/10.1016/j.isci.2021.102842.
6. Roy, N. H., M. Mammadli, J. K. 伯克哈德和M. Karimi. "Crkl Is Required for Donor T Cell Migration to Gvhd Target Organs." Oncotarget 11, no. (2020年4月28日):1505-14. http://www.frontiersin.org/articles/10.3389/fimmu.2020.593863/full.
7. Karimi, M. A., O. Aguilar, B. Zou, M. H. Bachmann, J. R. Carlyle, C. L. 鲍德温和T. Kambayashi. "A Truncated Human Nkg2d Splice Isoform Negatively Regulates Nkg2d-Mediated Function." J Immunol 193, no. (2014年9月15日):2764-71. http://dx.doi.org/10.4049/jimmunol.1400920.
8. Karimi, M. A., J. L. Bryson, L. P. Richman, A. D. Fesnak, T. M. Leichner, A. Satake, R. H. Vonderheide D. H. Raulet, R. Reshef和T. Kambayashi. "Nkg2d Expression by Cd8+ T Cells Contributes to Gvhd and Gvt Effects in a Murine Model of Allogeneic Hsct." Blood 125, no. 23(2015年6月4日):3655-63. http://dx.doi.org/10.1182/blood-2015-02-629006.
9. Karimi, M. A., E. Lee, M. H. Bachmann, A. M. Salicioni, E. M. Behrens, T. C. L. Baldwin. "Measuring Cytotoxicity by Bioluminescence Imaging Outperforms the Standard Chromium-51 Release Assay." PLoS One 9, no. 2 (2014): e89357. http://dx.doi.org/10.1371/journal.pone.0089357.
10. Karimi, M., T. M. Cao, J. A. Baker, M. R. Verneris, L. Soares和R. S. Negrin. "Silencing Human Nkg2d, Dap10, and Dap12 Reduces Cytotoxicity of Activated Cd8+ T Cells and Nk Cells." J Immunol 175, no. (2005年12月15日):7819-28. http://dx.doi.org/10.4049/jimmunol.175.12.7819.

健康连线电台的访谈节目